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KMID : 0387420090200020121
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Korean Society of Oriental Neuropsychiatry
2009 Volume.20 No. 2 p.121 ~ p.131
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Study of Anti-Alzheimer Activities from Scrophularia buergeriana Water Extract by Alzheimer’s Protein APP-transgenic Fly
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Kang Hyung-Won
Lyu Yeoung-Su
Kim Tae-Heon
Kim Jin-Woo
Lee Jong-Hwa
Lee Soon-Yee
Min Sang-Jun
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Abstract
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Objectives: From Scrophularia buergeriana water extract(SBW), has been used in vivo test for its beneficial effects on neuronal survival and neuroprotective functions, particularly in connection with APP-related dementias and Alzheimer’s disease(AD). Aβ oligomer derived from proteolytic processing of the β-amyloid precursor protein(APP), including the amyloid-β peptide(Aβ), play a critical role in the pathogenesis of Alzheimer’s dementia.
Methods: Using drosophila APP model on APP-induced neuronal cytotoxicity, we demonstrated that SBW prevents neurotoxicity of Aβ oligomer, which are the behavior, and possibly causative, feature of AD. We investigated the neuroprotective effects of SBW against the effects of oligomeric Aβ and fly behaveior and life span by UAS-GRIM/APP-GAL within transgenic flies.
Results and Conclusion : SBW repaired damage leading to the behaveior of APP-induced fly and delayed life span. These results suggest that neuronal damage in AD might be due to two factors: a direct Aβ oligomer toxicity and multiple cellular and molecular neuroprotective mechanisms, including attenuation of apoptosis and direct inhibition of Aβ oligomer, underlie the neuroprotective effects of SBW.
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KEYWORD
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Scrophularia buergeriana, Drosophila, Alzheimer’s disease, APP
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